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Hyaluronidase from Bovine Testes

Hyaluronidase from Bovine Testes

Synonyms Hyaluronate Glycanohydrolase; Hyaluronate lyase; chondroitinase; :Hyaluronoglucosaminidase Hyaluronate 4-glycanohydrolase

CAS Number: 37326-33-3

EC Number: 253-464-3 MDL Number: MFCD00131351

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SKU 02100740-CF
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Description

Product Description

Hyaluronidase

Application Notes

Testicular hyaluronidase hydrolyzes the endo-N-acetylhexosaminic bonds of hyaluronic acid and chondroitin sulfuric acids A and C (but not B), primarily to tetrasaccharide residues. Monosaccharides are not liberated. Hyaluronidase is often used in conjunction with collagenase to dissociate the extracellular matrix between cells of animal tissue, in order to release viable cells for use in tissue culture. It may also be used to clarify synovial fluids in order to make cell counts possible.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Drug dispersion & delivery

Specifications
SKU 02100740-CF
Application Notes Testicular hyaluronidase hydrolyzes the endo-N-acetylhexosaminic bonds of hyaluronic acid and chondroitin sulfuric acids A and C (but not B), primarily to tetrasaccharide residues. Monosaccharides are not liberated. Hyaluronidase is often used in conjunction with collagenase to dissociate the extracellular matrix between cells of animal tissue, in order to release viable cells for use in tissue culture. It may also be used to clarify synovial fluids in order to make cell counts possible.
Biochemical Physiological Actions Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression. These enzymes randomly cleave β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates.
EC Number 253-464-3
Extinction Coefficient ~8 (lit.)
Format Lyophilized powder form
Gene ID 281838
Gene Symbol and Aliases HYAL1, HYAL2
Hazard Statements H317
Applications Drug dispersion & delivery
Pack Size No
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Physical Appearance Tan Powder
Product Families Description Hyaluronidase
Product Overview Hyaluronidase
Source Bovine Testes
Specific Activity ≥300 USP u/mg
Specificity Testicular hyaluronidase hydrolyzes the endo-N-acetylhexosaminic bonds of hyaluronic acid and chondroitin sulfuric acids A and C (but not B); primarily to tetrasaccharide residues. Monosaccharides are not liberated
Storage and Handling -20 °C
Unit Definition Amount of enzyme which liberates one micromole of N-acetylglucosamine per minute at 37°C and pH 4.0
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.